Atlas of Drug Response

"A proteome-wide atlas of drug mechanism of action" is a publication that presents results of a large-scale proteomic study designed to understand how the proteome (the complete set of proteins expressed by a cell) responds to different chemical compounds.

The study, which was conducted in the Gygi Lab, used advanced instrument acquisition technologies and high-throughput proteomics to profile 875 compounds from a mechanism of action (MOA) library. The researchers used these data to define the protein complement to RNA-based MOA deconvolution resources such as CMAP, providing a comprehensive view of how chemical perturbations affect the proteome.

The results of this study have significant implications for our understanding of drug response, resistance pathways, compound off-targets, and protein codependencies in chemically perturbed cells. This proteome-wide atlas of drug MOA will serve as a valuable resource for researchers studying the mechanisms of action of drugs and other chemical compounds.

Publication:
https://lnkd.in/gHFtXgpa

Authors:
Dylan Mitchell
Miljan Kuljanin
Jiaming Li
Jonathan Van Vranken
Nathan Bulloch
Devin Schweppe

Affiliations:
Harvard Medical School - Gygi Lab
Gygi Website: https://lnkd.in/gwFTFmq7

University of Washington - Schweppe Lab
Schweppe Website: https://lnkd.in/g-FVgY7u